Book Summary:
It's official. Our tendencies to be happy or sad come in part from our genes. Samuel H. Barondes is a neurobiologist and psychiatrist at the University of California, San Francisco, and his direct involvement with the subject lends friendly authority to the book. Examining manic depression as a case study, Barondes shows how this strange condition--thought to have been instrumental in the ups and downs of Dickens, van Gogh, and Newton, among others--is definitely heritable. Although the specific gene or genes associated with the disorder haven't been identified, Barondes's account of the search is fascinating. We know that the likelihood of developing many physical diseases, such as diabetes, is determined by genes. But can abnormalities in specific genes also play a part in the development of mental disorders? And, if so, can these genes actually be identified and their discovery put to use in
prevention and treatment?
In Mood Genes, leading psychiatrist and biological researcher Samuel Barondes answers these questions in a way that renders a complex subject both exciting and understandable. Focusing on manic depressive illness, which affects about one percent of the population and has long been known to run in
families, Barondes describes the fascinating hunt for genes--called mood genes--that influence the inherited vulnerability to severe mood disorders. He builds the compelling story of this hunt on the histories of two families riddled with manic-depression, explaining what it means to have an
inherited predisposition to a severe mood disorder, how to find the mood genes that are responsible, and what will happen as mood genes are found.
Not long ago, saying that a behavioral tendency was genetic was generally taken to mean that it was unchangeable. Now we know that finding genes that influence particular behavioral variations may not just be used to foretell our destinies--but also to forestall them. |