 | Nonparametric clustering and model selection with application in bioinformatics -- Dissertation
by Wenxuan, Zhong
Publisher: ProQuest / UMI
Publication Date: Friday, August 18, 2006
Description: Because of recent development in biotechnology, more and more high dimensional and highly correlated data have been generated. Extracting useful information from these data is a challenging issue for modern statisticians and biologists. My dissertation focuses on developing method and theory for analyzing two types of these data: temporal gene...more
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 | Studies on several bioinformatics problems with machine learning techniques -- Dissertation
by Haifeng, Li
Publisher: ProQuest / UMI
Publication Date: Thursday, August 17, 2006
Description: The completion of the sequencing of the human genome was heralded the dawn of a new era in biology and medicine. Besides, advances in microarray technologies enable us to simultaneously observe the expression levels of many thousands of genes on the transcription levels during important biological processes. Such a global...more
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 | Pattern discovery in structural databases with applications to bioinformatics
by Sen Zhang
Publisher: ProQuest / UMI
Publication Date: Monday, March 20, 2006
Description: Frequent structure mining (FSM) aims to discover and extract patterns frequently occurring in structural data such as trees and graphs. FSM finds many applications in bioinformatics, XML processing, Web log analysis, and so on. In this thesis, two new FSM techniques are proposed for finding patterns in unordered labeled trees....more
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 | Model selection in kernel machine classification with applications in bioinformatics
by III Aden, James K.
Publisher: ProQuest / UMI
Publication Date: Sunday, March 19, 2006
Description: The focus of this dissertation is concerned with methods of model selection and parameter optimization associated with kernels for support vector machines. Two popular sub-sampling methods are cross-validation and bootstrapping, which are used to estimate the generalization error. Newer methods have been developed recently that use probability bounds associated with...more
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 | Bioinformatics and cell-free protein expression for enzyme engineering
by Mary Kathleen Williams DiTursi
Publisher: ProQuest / UMI
Publication Date: Sunday, March 19, 2006
Description: Bioinformatics and cell-free protein expression have shown themselves to be natural allies to metabolic engineering efforts. Bioinformatic techniques require information in order to tie proteins to each other, to tie sequence to structure and function. Here we demonstrate the use of the Bayesian sequence-based bioinformatics algorithms PROBE and Classifier to...more
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 | Redundancy-based feature selection for high-dimensional data and application in bioinformatics
by Lei Yu
Publisher: ProQuest / UMI
Publication Date: Sunday, March 19, 2006
Description: This dissertation studies feature selection: the problem of selecting a subset of features from the original ones in a data set. In many applications such as genomic microarray analysis and text document categorization, data often contains thousands of features. Many of them can be irrelevant or redundant to classification tasks....more
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 | Functional bioinformatic studies in erythrocyte remodeling by malaria parasites
by N. Luisa Hiller
Publisher: ProQuest / UMI
Publication Date: Sunday, March 19, 2006
Description: The human malaria parasite Plasmodium falciparum infects and develops within erythrocytes. This stage of infection is responsible for all the symptoms and pathologies of disease. In the intraerythrocytic stage, the parasite extensively remodels the host cell, presumably by delivering parasite effectors during invasion and development. The ligands involved in modification...more
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 | Markov chain Monte Carlo applications in bioinformatics and astrophysics
by Hosung Kang
Publisher: ProQuest / UMI
Publication Date: Saturday, March 18, 2006
Description: This thesis comprises three applications of Markov chain Monte Carlo methods in astrophysics and bioinformatics. The recent development of high resolution satellite telescopes and the technological advances in genotyping technologies for Single-Nucleotide Polymorphisms (SNPs) have given us a wealth of data in astrophysics and genetics and tremendous opportunities for statisticians...more
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 | Structural bioinformatics approach in determining the functional aspects of the polymerase associated domain in Y-family DNA polymerases
by Deborah Ann Josko
Publisher: ProQuest / UMI
Publication Date: Saturday, March 18, 2006
Description: Structural bioinformatics, the branch of bioinformatics that refers to three-dimensional macromolecular structures, utilizes various computational tools to infer protein function, establish evolutionary relationships, determine shape and electrostatic properties of proteins, etc. Structural bioinformatics was used to analyze the fingers subdomain of various DNA polymerase families, enzymes essential to DNA replication....more
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 | Wavelet methods and statistical applications: Network security and bioinformatics
by Deukwoo Kwon
Publisher: ProQuest / UMI
Publication Date: Saturday, March 18, 2006
Description: Wavelet methods possess versatile properties for statistical applications. We would like to explore the advantages of using wavelets in the analyses in two different research areas. First of all, we develop an integrated tool for online detection of network anomalies. We consider statistical change point detection algorithms, for both local...more
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